ALSUntangled No. 34: GM604

A Phase 2A randomized, double-blind, placebo-controlled pilot trial of GM604 in patients with Amyotrophic Lateral Sclerosis (ALS Protocol GALS-001) and a single compassionate patient

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that lacks effective treatment options. Genervon has discovered and developed GM604 (GM6) as a potential ALS therapy. GM6 has been modeled upon an insulin receptor tyrosine kinase binding motoneuronotrophic factor within the developing central nervous system. Methods This was a 2-center phase 2A, randomized, dou...

A Phase 2A randomized, double-blind, placebo-controlled pilot trial of GM604 in patients with Amyotrophic Lateral Sclerosis (ALS Protocol GALS-001) and a single compassionate patient

Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that lacks effective treatment options. Genervon has discovered and developed GM604 (GM6) as a potential ALS therapy. GM6 has been modeled upon an insulin receptor tyrosine kinase binding motoneuronotrophic factor within the developing central nervous system. Methods This was a 2-center phase 2A, randomized, dou...

ALSUntangled No. 7: Investigating hyperimmune goat serum (Aimspro) for ALS.

The mechanism of Aimspro remains unproven; if it is an immunomodulator and/or a modulator of sodium channels, it theoretically could be useful in ALS. A single, detailed but significantly flawed case report documents slowing in decline of certain respiratory functions in a patient claiming to have ALS, who started Aimspro shortly after bipap. Based upon this limited information, ALSUntangled su...

ALSUntangled Update 2: investigating the Hickey Wellness Center.

Now six months old, ALSUntangled (1) has 85 followers on twitter, and receives weekly questions about alternative and off-label ALS therapies. Our NING has 40 ALS clinician-scientists from four countries examining these therapies, with 18 active discussions. New discussions underway since our last update (2) include: intravenous glutathione, the Lourdes ALS Miracle, and the Nepsis Institute. Re...

ALSUntangled update 4: investigating the XCell-Center.